![]() The novel device consists of a chamber of 11 mm in diameter. The rabbits were 7 to 10 weeks old at the time of treatment. The small sample size was considered sufficient because a substantial effect was expected. ![]() The rabbits, three female and five male, were randomly selected from an albino colony. The number of rabbits was selected based on accepted sample size calculators. To plastically deform the living cornea we applied a vacuum to the cornea of eight rabbits and five human eyes with a novel device. Additional informed consent was obtained from all individual participants for whom identifying information is included in this article. Informed consent was obtained from all individual participants included in the study. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Similar content being viewed by othersĪll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board of the Hospital de la Cruz Roja in Barcelona and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. A flatter cornea corrects or reduces myopia. A vacuum chamber with radial openings alters the collagen fibers in the stroma and flattens the cornea. The method described here–Pneumatic Keratology– can be used to alter the cornea by non-invasive means. The deformation of the cornea was plastic, and therefore permanent. An anatomical modification of the cornea of humans and rabbits was achieved. Here we show that a strain can be achieved in vivo with a force produced by the application of the specially designed chamber where air is evacuated. The chamber is radially divided into four interconnected sub-chambers. This device consists of a chamber of 11 mm in diameter. To plastically deform the living cornea, we applied a vacuum to the cornea of eight rabbits and five human eyes with a novel device. This report seeks to demonstrate that the central radius of a patient’s cornea can be altered in a controlled manner designed to correct refractive errors. The phenomenon, however, has never been observed or produced on living tissue. Such permanent strain is referred to as ‘plastic’ strain. If the force is large enough, the cornea strains beyond the elastic range, and a permanent deformation occurs. The eyeball and, in particular, the cornea deform in vitro by the application of a distending force like other visco-elastic tissue.
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